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Search Result For 'Prognostic value of TWIST1 and EZH2 expression in colon cancer' , Result Number : 3
Staff Name
Research Area
Tayseer Refaat Ibrahim Elsayed
Faculty Research Area On Zu Site
Faculty Research Area On Staff Site
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer Samar M. Abdelraouf , Taiseer R. Ibrahim, Lobna A. Abdelaziz, Mohamed I. Farid, Salem Y. Mohamed Abstract Background :Colorectal carcinoma (CRC) is the third most common human cancer. Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. Also, the enhancer of Zeste homolologue2 (EZH2), a member of the polycomb group of genes, had been associated with poor prognosis in several malignancies. Objective :To evaluate the expression of Twist1 and EZH2 in colon carcinoma in Egyptian patients and its relation to clinico-pathological parameters, prognosis, and survival. Methods: Twist1 and EZH2 expressions were evaluated immunohistochemically in 50 cases of colorectal tumors (12 colon adenomas and 38 colon carcinomas) and 20 samples from normal colonic mucosa. Results :The expression of Twist1 and EZH2 was significantly higher in colon adenoma and carcinoma than that in normal colonic mucosa (P< 0.05). Twist1 and EZH2 expressions were associated with decreased tumor differentiation, advanced stage, and lymph node metastasis. Twist1 and EZH2 expressions were significantly related to 3-year disease-free survival (P=0.005 and 0.002 respectively) and 3-year overall survival (P= 0.045 and 0.039, respectively). Conclusions:Twist1 and EZH2 may serve as prognostic predictors for colon carcinoma and may have a potential role as therapeutic targets in patients with colon carcinoma in the future.
Samar Mosaad Abdelraouf
Faculty Research Area On Zu Site
Faculty Research Area On Staff Site
Prognostic value of TWIST1 and EZH2 expression in colon cancer
Lubna Abdul -Aziz Abdul- Aziz Muhamed
Faculty Research Area On Zu Site
Faculty Research Area On Staff Site
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer
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